Towards a “4I” approach to personalized healthcare
1 The Ohio State University Wexner Medical Center, Department of Biomedical Informatics, 3190 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
2 The Ohio State University Wexner Medical Center, Department of Internal Medicine and Center for Personalized Healthcare, 260 Meiling Hall, 370 West 9th Ave, Columbus, OH, 43210
3 Center for Personalized Healthcare, The Ohio State University Wexner Medical Center, Columbus, OH, USA
Clinical and Translational Medicine 2012, 1:14 doi:10.1186/2001-1326-1-14Published: 30 July 2012
Personalized healthcare holds the promise of ensuring that every patient receives optimal wellness promotion and clinical care based upon his or her unique and multi-factorial phenotype, informed by the most up-to-date and contextually relevant science. However, achieving this vision requires the management, analysis, and delivery of complex data, information, and knowledge. While there are well-established frameworks that serve to inform the pursuit of basic science, clinical, and translational research in support of the operationalization of the personalized healthcare paradigm, equivalent constructs that may enable biomedical informatics innovation and practice aligned with such objectives are noticeably sparse. In response to this gap in knowledge, we propose such a framework for the advancement of biomedical informatics in order to address the fundamental information needs of the personalized healthcare domain. This framework, which we refer to as a “4I” approach, emphasizes the pursuit of research and practice that is information-centric, integrative, interactive, and innovative.